Enhancing clinical trial development for pediatric kidney diseases

Clinical Signs, Causes, and Risk Factors of Pediatric Chronic Kidney Diseases: a Hospital-based Case-control Study

Background This retrospective study aimed to determine the epidemiologic characteristics and risk factors of chronic kidney diseases (CKD) in patients < 18 years old at a single referral center. Materials and Methods In a hospital-based case control study, 66 CKD patients less than 18 years old were compared to 81 control patients (also under 18) without CKD. A patient was defined as a CKD case...

Expression of nephrin in pediatric kidney diseases.

Nephrin is a podocyte cell adhesion protein located at the slit diaphragm area of the kidney glomerulus. Mutations in the nephrin gene (NPHS1) lead to congenital nephrosis, suggesting that nephrin is essential for the glomerular filtration barrier. This prompted this study of the expression of nephrin in acquired pediatric kidney diseases using in situ hybridization and immunohistochemistry. In...

Uniform clinical trial registration policy for journals of kidney diseases, dialysis, and transplantation.

Clinical prediction rules and pediatric infectious diseases.

Clinical prediction rules (CPR) are tools including appropriately weighted clinical aspects (history, physical examination and/or complementary tests) showing the odds for a specific diagnosis or prognosis. Their development includes a complex and strict process to achieve the scientific strength which supports use in clinical settings. Although CPR may be developed for almost any clinical situ...

Pediatric kidney transplantation: An overview

Kidney Transplantation in children is the treatment of choice to treat end stage renal disease. Improvements in immunosuppressive management have dramatically reduced the risk of early acute rejection and graft loss, however the long term results in terms of graft survival and morbidity still require search for new immunosuppressive regimens. Reducing of side effects are the challenges for impr...